Collagen is the main protein found in the connective tissue. It helps maintain the firmness, tone, and plumpness of the skin, making it a valuable ally against skin aging. Therefore, collagen is one of the main factors that contribute to maintaining healthy skin. As we age, the synthesis of new collagen decreases and its breakdown increases. The supply of type I collagen in the dermis stimulates the cells used for its production, called fibroblasts, to reproduce the production of neocollagen. Since the contribution of collagen is effective from the outside, it is important to ensure that its properties are perfectly maintained even after extraction. The production technology must strictly respect its biological structure and maintain its purity without any chemical residues.

Collagen is a fibrous protein that makes up the ECM of human tissues, including skin, tendons, ligaments, cartilage, bone, and teeth. It accounts for approximately 25% of all proteins in the human body. Collagen plays an important role in the biological healing process by driving tissue repair. Its mechanical effect provides structural support that helps:

• Create a supporting structure (framework) for the recovery of lost substances
• Control the differentiation, migration, and synthesis of many cellular proteins
• Improve the physiological formation of fibroblasts, granulation tissue, and native collagen
• Facilitate the contact of platelets and coagulation factors (hemostasis)
• Support the formation of new capillaries (angiogenesis)

• Heterologous native type I collagen, due to its triple helix structure, can lead to effects that can be superimposed on tissue collagen.
• Of the various collagens derived from animals, the equine type does not carry the risks associated with bovine spongiform encephalopathy (BSE). It can be considered as the "gold standard".
• It is extracted from the horse tendon and purified by high-tech processes that do not alter its properties, making it compatible with autologous tissue collagen.

Equine type 1 collagen and hydrolyzed hypoallergenic elastin. Collagen, together with elastin, helps create the necessary supporting structure for the dermis, providing it with moisture and counteracting relaxation processes by giving the skin tone and elasticity.

Nithia Smooth is a unique formula that contains a non-toxic alternative, Argireline (Hexapeptide-8), which has been proven to be safer than BoNT and equally effective in reducing wrinkles.
Argireline in Nithya Smooth acts on neuromuscular synapses, relieves tension in the muscle, and thus creates a relaxation of the dermal condition that reduces fine lines for smoother skin.

• It visibly reduces expression lines and wrinkles, especially crow's feet and nasolabial folds.
• It can be used in combination to reduce BoNT toxicity in later treatment phases.

Protection and improvement of skin tone

• Improves skin tone and texture
• Properly hydrates and reduces wrinkles
• Protects against oxidative stress
• Accelerates cell renewal.

Stimulates skin firmness to slow down signs of skin aging

• Increases skin firmness and elasticity
• Reduces wrinkles, stretch marks, and scars
• Maintains proper skin moisture